The instructions that make us who we are translate into a diverse array of complex and highly regulated processes that occur precisely and on time in every single cell. Mistakes in these processes can lead to disease. Scientists at the Max Perutz Labs study fundamental cellular and developmental processes at a mechanistic level.
Genetic information is encoded in genes, embedded in chromatin, and organized in chromosomes. Its implementation is dynamically regulated at different levels from DNA to RNA. At the Max Perutz Labs, scientists focus on fundamental processes of inheritance, nuclear architecture, genome organization, and RNA biology from bacteria to humans.
Malfunctions in our defense systems account for more than 85% of all human deaths. Max Perutz Labs scientists dissect the molecular mechanisms underlying the regulation of immune tolerance, signaling pathways in sterile and pathogenic inflammation, including cancer, as well as the principal mechanisms of immune surveillance in healthy, autoimmune, and infectious disease settings.
Biological processes are driven by the coordinated interaction of molecules within cells and tissues. The Max Perutz Labs studies how structure is related to function, the dynamics and energetics of the macromolecules that are at the heart of these processes, and the networks in which they operate. We aim to elucidate the mechanisms that shape our normal physiology and rationalize the role of aberrant macromolecules in disease.
Starting in April 2024
Erinc Hallacli
Deciphering molecular phenotypes in neurodegenerative diseases
Chromatin as a gatekeeper of chromosome replication
Mind matters. VBC mental health awareness
The multiple facets of Hop1 during meiotic prophase
Chromosomes as Mechanical Objects: from E.coli to Meiosis to Mammalian cells
Convergent evolution of CO2-fixing liquid-liquid phase separation
Viral envelope engineering for cell type specific delivery
New ways of leading: inclusive leadership and revising academic hierarchies
How an opportunistic human pathogen colonizes surfaces - From pathogen behavior to new drugs
Title to be announced
Decoding Molecular Plasticity in the Dark Proteome of the Nuclear Pore Complex
Probing the 3D genome architectural basis of neurodevelopment and aging in vivo
How to tango with four - the evolution of meiotic chromosome segregation after genome duplication
Multidimensional approach to decoding the mysteries of animal development
Connecting mitotic chromosomes to dynamic microtubules - insight from biochemical reconstitution
Membrane remodeling proteins at the junction between prokaryotes and eukaryotes
Neurodiversity in academia: strengths and challenges of neurodivergence
Gene expression dynamics during the awakening of the zygotic genome
When all is lost? Measuring historical signals
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Bacterial cell envelope homeostasis at the (post)transcriptional level
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced